Israel has shot down a Syrian missile using its most advanced anti-missile system for the first time, Israeli media say.
A surface-to-air missile (SAM) was intercepted using the Arrow system, designed to stop long-range ballistic missiles, reports say.
And in a rare admission, Israel said it had targeted several sites in Syria.
The intercepted SAM is reported to have come down in Jordan. Two others are said to have landed in Israel.
There were no reports of any injuries.
A serious escalation: By Jonathan Marcus, BBC defence correspondent
This episode is unusual on a number of counts. It is rare for Israel to admit to air strikes in Syria though there have been reports of at least four similar raids against Hezbollah weapons shipments since the start of December of last year.
This also looks to be the first operational use of Israel’s Arrow anti-ballistic missile system – launched possibly at an errant Syrian surface-to-air missile – that might have landed in Israeli territory.
The incident – not least because the Israel Defense Forces (IDF) statement has made it “official” – represents a serious escalation in tensions between Israel and Syria.
It comes less than 10 days after the Israeli Prime Minister Benjamin Netanyahu visited Moscow for talks with Vladimir Putin. Russian radars and aircraft control a significant slice of Syrian air space.
It’s a signal perhaps to all concerned that if weapons supplies to Hezbollah continue, then Israel is ready to escalate its air campaign.
There has been sporadic cross-border fire between the two countries since the start of the Syrian war in 2011.
Air strikes, said to have been carried out by Israel, have hit sites in Syria on numerous occasions, reportedly targeting weapons shipments for Lebanon’s Shia militant movement Hezbollah.
Shells, mostly believed to be stray from the fighting in Syria, have also landed in the Israel-occupied Syrian Golan Heights. Syria has also previously fired anti-aircraft missiles at Israeli fighter planes over its airspace, although none are known to have been hit.
Syria’s state news agency Sana said on Friday that Syrian forces had shot down one of four Israeli planes which had carried out overnight raids. The IDF however said none of its aircraft had been “compromised”.
The Israeli military said its planes were already back in Israeli airspace when the SAMs were fired.
Israeli media said one missile was intercepted by the Arrow system north of Jerusalem.
Pictures and video on social media showed a group of people gathered round what were said to be the burnt remains of a missile embedded in the ground amid twisted metal beside a building in Jordan.